Sybulski S
Obstet Gynecol. 1977 Sep;50(3):308-12.
Cortisol concentrations in umbilical cord plasma at birth were determined in association with pregnancy complications which may affect the time of pulmonary maturation of the fetus or otherwise influence its survival. No statistically significant change in these cortisol levels was observed in either term or premature pregnancies with the following complications: maternal disorder (preeclampsia, diabetes, pruritus), prolonged rupture of membranes, antenatal isoxsuprine treatment, maternal cigarette smoking, and neonatal asphyxia. Significant increases were observed in premature births in association with intrauterine fetal growth retardation and with the appearance of meconium. Cortisol concentrations in more severe forms of diabetes were significantly less than in Class A diabetes, in premature cases, and also tended to be low in association with various fetal congenital abnormalities. The possible physiologic significance of these results is discussed.
测定了出生时脐带血中皮质醇的浓度，并将其与可能影响胎儿肺成熟时间或影响其存活的妊娠并发症相关联。在足月或早产并伴有以下并发症的情况下，这些皮质醇水平均未观察到统计学上的显著变化：母体疾病（先兆子痫、糖尿病、瘙痒症）、胎膜早破、产前异克舒令治疗、孕妇吸烟和新生儿窒息。与宫内胎儿生长受限和胎粪出现相关的早产中，皮质醇浓度显著升高。在早产病例中，较严重类型糖尿病患者的皮质醇浓度显著低于 A 类糖尿病患者，并且与各种胎儿先天性异常相关时也往往较低。讨论了这些结果可能的生理意义。
