Thirunavukkarasu C, Singh J P, Selvendiran K, Sakthisekaran D
Department of Medical Biochemistry, Dr ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, India.
Cell Biochem Funct. 2001 Dec;19(4):265-71. doi: 10.1002/cbf.924.
The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N-nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in hepatoma and surrounding tissues of hepatoma-bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose- and duration-dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis.
研究了亚硒酸钠对环境致癌物N-亚硝基二乙胺诱导的肝癌的化学预防/化疗作用，观察了肝癌荷瘤大鼠肝癌组织及周围组织中三羧酸循环关键酶如异柠檬酸脱氢酶（ICDH）、琥珀酸脱氢酶（SDH）、苹果酸脱氢酶（MDH）和α-酮戊二酸脱氢酶（α-KGDH）活性的降低情况。补充硒后，上述生化变化以剂量和时间依赖的方式得到逆转。本研究进一步证实了亚硒酸钠的化学预防/化疗作用，发现其在致癌作用的起始阶段更有效。
