[低动力状态下大鼠肝脏三羧酸循环氧化酶的活性]
[Activity of oxidative enzymes of the tricarboxylic acid cycle in the liver of rats during hypokinesia].
作者信息
Ganin Iu A
出版信息
Kosm Biol Aviakosm Med. 1983;17(1):67-71.
The activity of oxidative enzymes of the Krebs cycle was examined in white rats during hypokinesia. On hypokinesia day 7 the cytosol activity of NAD-dependent isocitrate dehydrogenase (ICDH) increased and that of malic-enzyme decreased. On hypokinesia days 30 and 45 the activity of succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) decreased, that of cytoplasmatic malate dehydrogenases (MDH) slightly increased, and that of NADP ICDH declined. On hypokinesia day 60 the total activity of mitochondrial dehydrogenases reduced due to a low protein content of the mitochondrial fraction, whereas the specific activity either remained unchanged (ICDH, NAD MDH, alpha-KGDH) or increased (SDH, NADP MDH). On recovery day 25 only the activity of mitochondrial NAD-dependent malate and isocitrate dehydrogenases returned to normal.
在低动力状态下对白鼠克雷布斯循环氧化酶的活性进行了检测。在低动力状态第7天，NAD依赖的异柠檬酸脱氢酶（ICDH）的胞浆活性增加，而苹果酸酶的活性降低。在低动力状态第30天和第45天，琥珀酸脱氢酶（SDH）和α-酮戊二酸脱氢酶（α-KGDH）的活性降低，胞质苹果酸脱氢酶（MDH）的活性略有增加，而NADP ICDH的活性下降。在低动力状态第60天，由于线粒体部分蛋白质含量低，线粒体脱氢酶的总活性降低，而比活性要么保持不变（ICDH、NAD MDH、α-KGDH），要么增加（SDH、NADP MDH）。在恢复第25天，只有线粒体NAD依赖的苹果酸和异柠檬酸脱氢酶的活性恢复正常。
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