Caccamese S, Principato G, Jokela R, Tolvanen A, Din Belle D
Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy.
Chirality. 2001;13(10):691-3. doi: 10.1002/chir.10013.
The HPLC enantiomeric separation of racemic indole alkaloids tacamonine, 17 alpha-hydroxytacamonine, deethyleburnamonine, and vindeburnol was accomplished using Chiralpak AD and Chiralcel OD as chiral stationary phases. Small structural differences affect the enantioselectivity ability of these phases. Single enantiomers of tacamonine and vindeburnol were isolated by semipreparative HPLC and their CD spectra and optical rotations were measured.
使用Chiralpak AD和Chiralcel OD作为手性固定相，实现了外消旋吲哚生物碱塔卡莫宁、17α-羟基塔卡莫宁、去乙基伯恩莫宁和长春布醇的HPLC对映体分离。微小的结构差异会影响这些固定相的对映选择性能力。通过半制备HPLC分离出塔卡莫宁和长春布醇的单一对映体，并测量了它们的圆二色光谱和旋光度。
