Tavassoli M
Blood. 1975 Oct;46(4):631-5.
Multiple spleens were implanted in the subcutaneous tissue or the peritoneal cavity of inbred rats which had undergone splenectomy. The total weight of regenerated implants was compared to the weight of implanted tissue. The weight of recovered tissue was not a function of implanted spleen mass; rather, it approximated the unit ratio of the animal's own spleen. Those animals receiving more than ten spleens died by days 3-6 postimplantation, probably as a result of massive necrosis that occurred during the process of regeneration. When implants were made in a temporal sequence of two spleens every 3 days, the first set was uniformly successful, whereas regeneration was aborted in subsequent sets of implants. These observations are consistent with the conclusion that certain factors control the total mass of spleen in any one animal.
将多个脾脏植入已接受脾切除术的近交系大鼠的皮下组织或腹腔内。将再生植入物的总重量与植入组织的重量进行比较。回收组织的重量不是植入脾脏质量的函数；相反，它接近动物自身脾脏的单位比例。那些接受超过十个脾脏的动物在植入后3 - 6天死亡，可能是由于再生过程中发生的大规模坏死。当以每3天植入两个脾脏的时间顺序进行植入时，第一组植入均成功，而后续植入组的再生则中止。这些观察结果与某些因素控制任何一只动物脾脏总质量的结论一致。
