Ormai S, Palkovits M
Blut. 1975 Oct;31(4):239-46. doi: 10.1007/BF01633507.
Intravenous polymethacrylic acid (PMAA) significantly increases the number of lymphocytes in the blood of the rat. The relationship between dose-effect and lymphocytosis is linear. The lethal dose in 30 days of PMAA is 120 mg/kg b.w. and the half-lethal dose 80 mg/kg b.w. The treatment with 40 mg/kg b.w. intravenous PMAA gives no toxic histological changes either in the lymph organs, the liver or the kidneys. Thus, PMAA appears to be, at present, a most suitable agent by which to provoke experimentally, migration of the reserve lymphocytes into the blood.
静脉注射聚甲基丙烯酸（PMAA）可显著增加大鼠血液中的淋巴细胞数量。剂量效应与淋巴细胞增多之间呈线性关系。PMAA在30天内的致死剂量为120毫克/千克体重，半致死剂量为80毫克/千克体重。以40毫克/千克体重静脉注射PMAA进行治疗，在淋巴器官、肝脏或肾脏中均未产生毒性组织学变化。因此，目前PMAA似乎是一种最适合用于实验性激发储备淋巴细胞向血液中迁移的药物。
