消炎痛对体外致敏人支气管抗原诱导收缩的抑制作用。
Reduction of antigen-induced contraction of sensitized human bronchus in vitro by indomethacin.
作者信息
Dunlop L S, Smith A P
出版信息
Br J Pharmacol. 1975 Aug;54(4):495-7. doi: 10.1111/j.1476-5381.1975.tb07596.x.
Abstract
- Contraction of passively sensitized human bronchus induced by antigen challenge in vitro, was reduced by the prostaglandin F2alpha synthetase inhibitor, indomethacin. 2. Prostaglandin F2alpha was released during challenge and this release was inhibited by indomethacin. 3. There was a significant correlation between prostaglandin F2alpha release and antigen challenge-induced contraction, suggesting that this substance may contribute to the bronchoconstrictor response of sensitized human bronchus to antigen.
摘要
- 体外抗原激发诱导的被动致敏人支气管收缩，可被前列腺素F2α合成酶抑制剂吲哚美辛减弱。2. 激发过程中前列腺素F2α释放，且这种释放被吲哚美辛抑制。3. 前列腺素F2α释放与抗原激发诱导的收缩之间存在显著相关性，表明该物质可能促成致敏人支气管对抗原的支气管收缩反应。
相似文献
1
Reduction of antigen-induced contraction of sensitized human bronchus in vitro by indomethacin.消炎痛对体外致敏人支气管抗原诱导收缩的抑制作用。
Br J Pharmacol. 1975 Aug;54(4):495-7. doi: 10.1111/j.1476-5381.1975.tb07596.x.
2
Indomethacin enhances response of human bronchus to antigen.吲哚美辛增强人支气管对抗原的反应。
Am Rev Respir Dis. 1985 Jan;131(1):8-10. doi: 10.1164/arrd.1985.131.1.8.
3
Antigen-induced contraction of guinea-pig trachea: search for mediator release with cascade superfusion bioassay.抗原诱导的豚鼠气管收缩：采用级联灌流生物测定法探寻介质释放情况。
Br J Pharmacol. 1982 Sep;77(1):3-5. doi: 10.1111/j.1476-5381.1982.tb09261.x.
4
Studies of the mechanism of passive anaphylaxis in human airway smooth muscle.人类气道平滑肌被动过敏反应机制的研究。
Can J Physiol Pharmacol. 1983 Jul;61(7):705-13. doi: 10.1139/y83-109.
5
The effects of arachidonic acid, prostaglandin E2 and prostaglandin F2alpha on the longitudinal stomach strip of the rat.花生四烯酸、前列腺素E2和前列腺素F2α对大鼠胃纵行肌条的影响。
J Pharmacol Exp Ther. 1973 Dec;187(3):501-10.
6
The effects of arachidonic acid, indomethacin and SC-19220 on guinea-pig tracheal muscle tone.花生四烯酸、吲哚美辛和SC - 19220对豚鼠气管肌张力的影响。
Eur J Pharmacol. 1975 Feb;30(2):148-53. doi: 10.1016/0014-2999(75)90093-x.
7
Pharmacological characterization of airway smooth muscle responses to antigen in ascaris-sensitive dogs.蛔虫敏感犬气道平滑肌对抗原反应的药理学特征
Can J Physiol Pharmacol. 1986 Nov;64(11):1361-7. doi: 10.1139/y86-231.
8
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.豚鼠气管体外收缩反应：前列腺素合成抑制药物的影响
J Pharmacol Exp Ther. 1975 Sep;194(3):554-64.
9
Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma.人肺实质中血栓素A2、前列腺素D2和前列环素的过敏释放。
Am Rev Respir Dis. 1981 Oct;124(4):402-6. doi: 10.1164/arrd.1981.124.4.402.
10
The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig.大麻二酚对豚鼠气道平滑肌抗原诱导收缩的影响。
Pulm Pharmacol Ther. 2013 Jun;26(3):373-9. doi: 10.1016/j.pupt.2013.02.002. Epub 2013 Feb 18.
引用本文的文献
1
Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on Platelet Activating Factor and Eicosanoid Production By nasal Mucosa in Patients with A house Dust Mite Allergy.丙酸氟替卡松水剂鼻腔喷雾治疗对屋尘螨变应性患者鼻黏膜血小板激活因子和类二十烷酸产生的影响。
Mediators Inflamm. 1994;3(5):381-5. doi: 10.1155/S0962935194000530.
2
Anti-IgE Response in Human Airways: Relative Contribution of Inflammatory Mediators.人呼吸道中的抗 IgE 反应：炎症介质的相对贡献。
Mediators Inflamm. 1994;3(5):359-63. doi: 10.1155/S0962935194000505.
3
FPL 55712--an antagonist of slow reacting substance of anaphylaxis (SRS-A): a review. 1979.FPL 55712——过敏反应慢反应物质（SRS-A）拮抗剂综述。1979年
Agents Actions. 1994 Dec;43(3-4):168-75; discussion 167. doi: 10.1007/BF01986684.
4
The interaction between indomethacin and contractile agents on human isolated airway muscle.吲哚美辛与收缩剂对人离体气道平滑肌的相互作用。
Br J Pharmacol. 1980 Jul;69(3):383-8. doi: 10.1111/j.1476-5381.1980.tb07026.x.
5
Interactions between response to inhaled prostaglandin E2 and chronic beta-adrenergic agonist treatment.吸入性前列腺素E2反应与慢性β-肾上腺素能激动剂治疗之间的相互作用。
Thorax. 1982 Jun;37(6):430-7. doi: 10.1136/thx.37.6.430.
6
Contractile and relaxant actions of prostaglandins on guinea-pig isolated trachea.前列腺素对豚鼠离体气管的收缩和舒张作用。
Br J Pharmacol. 1980 Mar;68(3):533-9. doi: 10.1111/j.1476-5381.1980.tb14569.x.
7
Allergen tachyphylaxis of guinea pigs in vivo; a prostaglandin E mediated phenomenon?豚鼠体内变应原速发耐受；一种由前列腺素E介导的现象？
Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):351-6. doi: 10.1007/BF00501318.
8
Effect of histamine, acetylcholine and compound 48/80 on bronchoconstriction and release of eicosanoids in the dog.组胺、乙酰胆碱和化合物48/80对犬支气管收缩和类花生酸释放的影响。
Agents Actions. 1984 Oct;15(3-4):153-61. doi: 10.1007/BF01972342.
9
Stimulation of the antigen-induced contraction of guinea-pig trachea and immunological release of histamine and SRS-A from sensitized guinea-pig lung by (2-isopropyl-3-indolyl)-3 pyridyl ketone (L8027) and indomethacin.（2-异丙基-3-吲哚基）-3-吡啶基酮（L8027）和吲哚美辛对豚鼠气管抗原诱导收缩的刺激作用以及对致敏豚鼠肺中组胺和慢反应物质-A的免疫释放作用。
Br J Pharmacol. 1980;71(1):65-73. doi: 10.1111/j.1476-5381.1980.tb10910.x.
10
The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs.人支气管平滑肌的自发电活动和机械活动：药物对其的调节作用。
Br J Pharmacol. 1989 Dec;98(4):1249-60. doi: 10.1111/j.1476-5381.1989.tb12671.x.
本文引用的文献
1
Distribution of prostaglandins in human tissues.前列腺素在人体组织中的分布。
Br J Pharmacol Chemother. 1967;31(2):340-4. doi: 10.1111/j.1476-5381.1967.tb02003.x.
2
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
3
The isolation and determination of prostaglandins in lungs of sheep, guinea pig, monkey and man.绵羊、豚鼠、猴子和人类肺中前列腺素的分离与测定。
Biochem Pharmacol. 1965 Nov;14(11):1507-16. doi: 10.1016/0006-2952(65)90004-3.
4
Radioimmunoassay of prostaglandin F-2-alpha in peripheral venous plasma from men and women.男性和女性外周静脉血浆中前列腺素F-2-α的放射免疫测定
Prostaglandins. 1974 Mar 25;5(6):531-42. doi: 10.1016/s0090-6980(74)80028-6.
5
Bronchial hyperreactivity to prostaglandin F 2 and histamine in patients with asthma.哮喘患者对前列腺素F2和组胺的支气管高反应性。
Br Med J. 1973 Jan 27;1(5847):193-6. doi: 10.1136/bmj.1.5847.193.
6
The release of spasmogenic substances from human chopped lung tissue and its inhibition.人肺组织匀浆中致痉物质的释放及其抑制作用
Br J Pharmacol. 1973 Feb;47(2):291-304. doi: 10.1111/j.1476-5381.1973.tb08327.x.
7
Prostaglandin regulation of airway smooth muscle tone.前列腺素对气道平滑肌张力的调节。
Nat New Biol. 1973 Sep 19;245(142):84-5. doi: 10.1038/newbio245084a0.
8
Increased plasma levels of 15-keto-13,14-dihydro-prostaglandin F2X after allergen-provoked asthma in man.人类过敏原诱发哮喘后血浆中15-酮基-13,14-二氢前列腺素F2α水平升高。
Lancet. 1974 Dec 14;2(7894):1419-21. doi: 10.1016/s0140-6736(74)90075-0.
Zotero 插件