Burka J F
Br J Pharmacol. 1982 Sep;77(1):3-5. doi: 10.1111/j.1476-5381.1982.tb09261.x.
Ovalbumin induces contraction of sensitized guinea-pig trachea, both in the presence and absence of indomethacin. Cascade superfusion bioassay was employed to detect mediator release. A prostaglandin E-like material was released in response to antigen in the absence of indomethacin but, no biologically active material could be detected from trachea in the presence of indomethacin. Thus the substance responsible for antigen-induced tracheal contraction, although appearing to be a lipoxygenase product, is as yet undefined.
卵清蛋白在存在和不存在消炎痛的情况下均可诱导致敏豚鼠气管收缩。采用级联灌流生物测定法检测介质释放。在不存在消炎痛的情况下，抗原刺激可释放一种类前列腺素E物质，但在存在消炎痛的情况下，从气管中未检测到生物活性物质。因此，尽管负责抗原诱导气管收缩的物质似乎是一种脂氧合酶产物，但目前尚未明确。
