经颅磁刺激作用于抑郁成年人前额叶皮质的脑效应：刺激频率和线圈-皮质距离的作用
Brain effects of TMS delivered over prefrontal cortex in depressed adults: role of stimulation frequency and coil-cortex distance.
作者信息
Nahas Z, Teneback C C, Kozel A, Speer A M, DeBrux C, Molloy M, Stallings L, Spicer K M, Arana G, Bohning D E, Risch S C, George M S
机构信息
Brain Stimulation Laboratory, Functional Neuroimaging Research Division, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2001 Fall;13(4):459-70. doi: 10.1176/jnp.13.4.459.
Relative regional brain blood flow was measured in 23 clinically depressed adults by using ECD SPECT at baseline and again during actual prefrontal transcranial magnetic stimulation (TMS) following 5 daily sessions of TMS. TMS over prefrontal cortex caused increased activity in cortex directly under the stimulation (inversely correlated with distance from scalp to cortex) and decreased activity in remote regions (anterior cingulate and anterior temporal poles). High-frequency rTMS (20 Hz) caused more relative flow immediately below the TMS coil than did low-frequency rTMS (5 Hz). Confirming the hypotheses tested, repeated daily TMS over the prefrontal cortex in medication-free depressed adults appears to change both local and remote blood flow in a manner that may also depend on the frequency of stimulation and coil to outer cortex distance.
在23名临床抑郁症成年人中，通过使用ECD单光子发射计算机断层扫描（SPECT）在基线时测量相对局部脑血流量，并在连续5天进行前额叶经颅磁刺激（TMS）后的实际前额叶TMS期间再次测量。前额叶皮质的TMS导致刺激正下方皮质的活动增加（与从头皮到皮质的距离呈负相关），并导致远处区域（前扣带回和颞极前部）的活动减少。高频重复经颅磁刺激（rTMS，20赫兹）比低频rTMS（5赫兹）在TMS线圈正下方引起更多的相对血流量。证实了所测试的假设，在未服用药物的抑郁症成年人中，每天在前额叶皮质重复进行TMS似乎会以一种可能还取决于刺激频率和线圈到外层皮质距离的方式改变局部和远处的血流量。
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