Mental Illness Research, Education, and Clinical Center, VA Palo Alto Healthcare System (NCW, JAY, MRM), Palo Alto, CA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine (NCW, JAY, MRM), CA.
VA RR&D Center for Neurorestoration and Neurotechnology, VA Providence Healthcare System (NSP), Providence, RI; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University (NSP), Providence, RI.
Am J Geriatr Psychiatry. 2024 Mar;32(3):315-325. doi: 10.1016/j.jagp.2023.10.010. Epub 2023 Oct 22.
OBJECTIVE: While typical aging is associated with decreased cortical volume, major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) likely exacerbates this process. Cerebral atrophy leads to increased coil-to-cortex distance and when using transcranial magnetic stimulation (TMS), potentially reducing effectiveness in older adults. METHODS: Data from a large-scale quality improvement project was used. Included veterans eligible for TMS and completed TMS treatment. Age was assessed as a predictive factor of depression outcomes after TMS treatment among veterans. Secondary analyses examined the impact of age on 1) MDD response and remission and 2) MDD change within MDD-only verses comorbid MDD and PTSD groups. RESULTS: The entire sample included 471 veterans. Primary analysis revealed age as a negative predictor of depression outcomes (p = 0.019). Secondary analyses found age to be a significant predictor of remission (p = 0.004), but not clinical response. Age was not a predictive factor in depression outcomes between those with MDD-only compared to MDD+PTSD. CONCLUSIONS: Increased age predicts greater MDD symptom reduction after TMS. Although age did not predict response rates, it did predict increased rates of remission in veterans. Age did not differentially predict depression outcomes between those with or without PTSD. The sample size was sufficient to discern a difference in efficaciousness, and limitations were those inherent to registry studies in veterans. This data indicates that TMS can be an important treatment option for older individuals.
目的:虽然典型的衰老与皮质体积减少有关,但重度抑郁症(MDD)和创伤后应激障碍(PTSD)可能会使这一过程恶化。脑萎缩导致线圈到皮质的距离增加,当使用经颅磁刺激(TMS)时,可能会降低老年患者的治疗效果。
方法:使用了一项大规模质量改进项目的数据。包括有资格接受 TMS 治疗并完成 TMS 治疗的退伍军人。年龄被评估为退伍军人接受 TMS 治疗后抑郁结果的预测因素。二次分析检查了年龄对 1)MDD 反应和缓解率,以及 2)MDD 单一和合并 MDD 和 PTSD 组中 MDD 变化的影响。
结果:整个样本包括 471 名退伍军人。主要分析显示年龄是抑郁结果的负预测因子(p=0.019)。二次分析发现年龄是缓解的显著预测因子(p=0.004),但不是临床反应的预测因子。在 MDD 单一与 MDD+PTSD 组之间,年龄不是影响 MDD 结果的因素。
结论:年龄增加预示着 TMS 治疗后 MDD 症状的减轻更大。尽管年龄没有预测反应率,但它确实预测了退伍军人缓解率的增加。年龄对 PTSD 有无的患者的抑郁结果没有差异预测作用。样本量足以区分有效性的差异,并且局限性是退伍军人登记研究固有的。这些数据表明 TMS 可以成为老年患者的重要治疗选择。
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