Heikkilä M, Peltoketo H, Vainio S
Biocenter Oulu and Department of Biochemistry, FIN-90014 University of Oulu, Finland.
J Exp Zool. 2001 Nov 1;290(6):616-23. doi: 10.1002/jez.1112.
Wnts are intercellular growth and differentiation factors that regulate several key developmental steps, such as gastrulation, neurulation, and organogenesis, including the development of the midbrain, central nervous system, kidney, and limbs. Wnts are also needed for a normal development of the reproductive system. Deficiency of Wnt-4, -5a, and -7a, for example, results in sex reversal, infertility, and/or malformation of the internal and external genitals. Here we focus on the importance of Wnts in the female reproductive system.
Wnt蛋白是细胞间生长和分化因子，可调节多个关键发育步骤，如原肠胚形成、神经胚形成和器官发生，包括中脑、中枢神经系统、肾脏和四肢的发育。Wnt蛋白对生殖系统的正常发育也很重要。例如，Wnt-4、-5a和-7a的缺乏会导致性反转、不孕和/或内外生殖器畸形。在此，我们重点关注Wnt蛋白在女性生殖系统中的重要性。
