Sangiah S, Garrison D L, Nichols R A, Yim G K
Brain Res. 1975 Aug 15;93(3):409-18. doi: 10.1016/0006-8993(75)90180-8.
Cerebellar inhibition of spontaneous or homocysteic acid-induced activity of dorsal Deiters' neurons was studied in cats anesthetized with chloralose-urethane. Following intravenous lidocaine (5-10 mg/kg), cerebellar inhibition was not reduced but postinhibitory peaks (PIPs) appeared in the poststimulus histograms. The number of PIPs increased as variability in firing rate decreased after lidocaine. The frequency of PIPs observed in the histograms approximated the monitored firing rates of the cells. The peaks observed in autocorrelograms constructed after lidocaine had the same frequency, structure and variability as the PIPs. In 'dot diagrams', only one spike per corresponding PIP was observed. Similar PIPs were observed in poststimulus histograms constructed during inhibition of crayfish stretch receptor neurons which fired regularly in the absence of lidocaine. These studies indicate that the postinhibitory peaks and silent periods were due to synchronized firing of Deiters' neurons induced by cerebellar inhibition, which was detectable only after lidocaine regularized the firing of Deiters' neurons.
在使用水合氯醛-乌拉坦麻醉的猫身上，研究了小脑对背侧Deiters神经元自发活动或同型半胱氨酸诱导活动的抑制作用。静脉注射利多卡因（5-10mg/kg）后，小脑抑制作用并未减弱，但在刺激后直方图中出现了抑制后峰值（PIPs）。随着利多卡因作用后放电频率变异性降低，PIPs的数量增加。在直方图中观察到的PIPs频率接近所监测细胞的放电频率。利多卡因作用后构建的自相关图中观察到的峰值与PIPs具有相同的频率、结构和变异性。在“点图”中，每个相应的PIP仅观察到一个峰电位。在抑制小龙虾伸展感受器神经元期间构建的刺激后直方图中也观察到了类似的PIPs，这些神经元在没有利多卡因的情况下有规律地放电。这些研究表明，抑制后峰值和静息期是由小脑抑制诱导的Deiters神经元同步放电所致，只有在利多卡因使Deiters神经元放电规律化后才能检测到。
