延胡索对缺血再灌注损伤大鼠局灶性脑梗死的影响。

Effect of Rhizoma Corydalis on focal cerebral infarct in ischemia-reperfusion injured rats.

作者信息

Liao E T, Chiang S Y, Lao C J, Tang N Y, Hsieh C T, Lin J G

机构信息

Internal Medicine of Chinese Medicine Department, China Medical College Hospital, Taichung, Taiwan, China.

出版信息

Acta Pharmacol Sin. 2001 Dec;22(12):1143-8.

PMID:11749819

Abstract

AIM

To investigate the effect of Rhizoma Corydalis (RC) on focal cerebral infarct.

METHODS

A total of 30 Sprague-Dawley (SD) rats were studied. Focal cerebral infarct was established b y occluding the bilateral common carotid arteries and the right middle cerebral artery for 90 min. After 24 h reperfusion, the neurological status was evaluated and then the rats were killed and the brain tissue was stained with 2,3,5-triphenyl-tetrazolium chloride. The neurological status and the changes in the area of cerebral infarct were used as an index to evaluate the effect of RC on cerebral infarct. In addition, the whole blood was examined 24 h after RC treatment in the other 24 SD rats.

RESULTS

Pretreatment with RC 100 mg/kg can improve neurological status and also can reduce the area of cerebral infarct in ischemia-reperfusion injured rats. The counts of erythrocyte and the amount of hematocrit increased in whole blood of RC-treated rats.

CONCLUSION

RC can improve neurological status and reduce the area of cerebral infarct in ischemia-reperfusion injured rats.

摘要

目的

研究延胡索对局灶性脑梗死的影响。

方法

共研究30只Sprague-Dawley（SD）大鼠。通过阻断双侧颈总动脉和右侧大脑中动脉90分钟建立局灶性脑梗死模型。再灌注24小时后，评估神经功能状态，然后处死大鼠，用2,3,5-三苯基氯化四氮唑对脑组织进行染色。以神经功能状态和脑梗死面积变化作为评价延胡索对脑梗死影响的指标。此外，对另外24只SD大鼠在给予延胡索治疗24小时后检测全血。