Sharma P
Department of Medicine, University of Kansas School of Medicine, Kansas City, Missouri 64128, USA.
Am J Med. 2001 Dec 3;111 Suppl 8A:147S-152S. doi: 10.1016/s0002-9343(01)00825-7.
Barrett's esophagus is a complication of chronic gastroesophageal reflux disease and is characterized by replacement of the normal squamous mucosa in the distal esophagus with metaplastic columnar mucosa. It is the premalignant lesion for adenocarcinoma of the distal esophagus and the esophagogastric junction. Treatment of Barrett's esophagus includes controlling the underlying reflux with either proton pump inhibitor therapy or antireflux surgery. However, neither pharmacological nor surgical treatment has resulted in reversal of the metaplastic mucosa. Failure of conventional treatments has led to endoscopic ablation therapies-injury to the Barrett's esophagus with different forms of energy in combination with acid suppression. This article reviews the current status of different therapies for endoscopic reversal of Barrett's esophagus.
巴雷特食管是慢性胃食管反流病的一种并发症，其特征是远端食管的正常鳞状黏膜被化生的柱状黏膜所取代。它是远端食管和食管胃交界腺癌的癌前病变。巴雷特食管的治疗包括使用质子泵抑制剂治疗或抗反流手术来控制潜在的反流。然而，药物治疗和手术治疗均未使化生黏膜逆转。传统治疗方法的失败导致了内镜消融治疗——利用不同形式的能量对巴雷特食管造成损伤并联合抑酸治疗。本文综述了内镜下逆转巴雷特食管的不同治疗方法的现状。
