Falk G W
Cleveland Clinic Foundation, Ohio.
Gastrointest Endosc Clin N Am. 1994 Oct;4(4):773-89.
Barrett's esophagus is a complication of gastroesophageal reflux disease that is diagnosed with increasing frequency in connection with the increased utilization of upper endoscopy. It remains unclear why some patients with gastroesophageal reflux disease develop Barrett's esophagus while others do not. The association of Barrett's esophagus and adenocarcinoma is well established; if not for this fact, Barrett's esophagus would be of little clinical importance. Endoscopic surveillance with a rigorous biopsy protocol for the detection of dysplasia or early adenocarcinoma is indicated in any patient with Barrett's esophagus who is a candidate for surgery. New therapeutic strategies, including profound acid suppression with proton pump inhibitors, laser ablation of Barrett's epithelium, and photodynamic therapy, are currently under evaluation for the treatment of Barrett's esophagus.
巴雷特食管是胃食管反流病的一种并发症，随着上消化道内镜检查使用频率的增加，其诊断率也在不断上升。目前尚不清楚为什么有些胃食管反流病患者会发展为巴雷特食管，而另一些患者则不会。巴雷特食管与腺癌之间的关联已得到充分证实；若不是这一事实，巴雷特食管几乎没有临床意义。对于任何适合手术的巴雷特食管患者，均需采用严格的活检方案进行内镜监测，以检测发育异常或早期腺癌。目前正在评估包括使用质子泵抑制剂进行深度抑酸、激光消融巴雷特上皮以及光动力疗法在内的新治疗策略，用于治疗巴雷特食管。
