Massey B T
Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
Am J Med. 2001 Dec 3;111 Suppl 8A:186S-189S. doi: 10.1016/s0002-9343(01)00829-4.
Transient lower esophageal sphincter relaxations (TLESRs) are neurally mediated abrupt reductions in lower esophageal sphincter (LES) pressure. TLESRs are not usually associated with deglutition or secondary peristalsis but are thought to be necessary for venting swallowed air from the stomach. Their central role in acid reflux, however, makes them a compelling therapeutic target for patients with gastroesophageal reflux disease. Pharmacologic approaches for reducing TLESR frequency are being studied, but theoretically more promising are endoscopic approaches that interfere with mechanoreceptor function. Further study into the mechanisms of action of these approaches is needed, as are controlled clinical trials to define the true utility of these techniques and identify patients who will receive the most benefit.
短暂性下食管括约肌松弛（TLESRs）是由神经介导的下食管括约肌（LES）压力突然降低。TLESRs通常与吞咽或继发性蠕动无关，但被认为是胃内吞咽空气排出所必需的。然而，它们在胃酸反流中的核心作用使其成为胃食管反流病患者极具吸引力的治疗靶点。目前正在研究降低TLESR频率的药物方法，但从理论上讲，更有前景的是干扰机械感受器功能的内镜方法。需要进一步研究这些方法的作用机制，同时也需要进行对照临床试验，以确定这些技术的真正效用，并确定哪些患者将受益最大。
