Wright C J
Can J Surg. 1975 Sep;18(5):431-5.
The control of blood flow in skeletal muscle is incompletely understood, and for this reason the effect of sympathetic inhibition on muscle blood flow in the leg was studied. One group of patients selected for study comprised 20 patients without evidence of vascular disease; a second comprised 20 with peripheral occlusive arterial disease, in whom the site of occlusion varied from the aorta to the lower leg arteries. None had undergone previous vascular surgery or sympathectomy. Variables studied included resting muscle blood flow; maximal muscle blood flow; interval from tourniquet release to onset of peak flow; duration of peak blood flow; muscle blood flow after tourniquet release; and skin temperature in the foot. Muscle blood flow was calculated from xenon-133 clearance. The variables were studied before and after ischemic (thigh tourniquet) and before and after sympathetic inhibition (immersion of hands and wrists in water at 45 degrees C). The significant differences between the two groups related to peak flow after ischemic exercise, the interval from tourniquet release to peak flow and duration of peak flow. Sympathetic inhibition was followed by no significant changes in maximal muscle blood flow, though there was a significant decrease in resting muscle blood flow. The results of the present study, in which noninvasive sympathetic blockade was used, confirm the findings of others that muscle blood flow does not change after operative sympathectomy.
骨骼肌血流的控制尚未完全明了，因此，研究了交感神经抑制对腿部肌肉血流的影响。入选研究的一组患者包括20例无血管疾病证据的患者；另一组包括20例患有外周闭塞性动脉疾病的患者，其闭塞部位从主动脉到小腿动脉各不相同。所有患者均未接受过血管手术或交感神经切除术。研究的变量包括静息肌肉血流、最大肌肉血流、从松开止血带到血流峰值开始的间隔时间、血流峰值持续时间、松开止血带后的肌肉血流以及足部皮肤温度。肌肉血流通过氙-133清除率计算得出。在缺血（大腿止血带）前后以及交感神经抑制（将手和手腕浸入45摄氏度的水中）前后对这些变量进行了研究。两组之间的显著差异与缺血运动后的血流峰值、从松开止血带到血流峰值的间隔时间以及血流峰值持续时间有关。交感神经抑制后，最大肌肉血流无显著变化，尽管静息肌肉血流显著降低。本研究采用非侵入性交感神经阻滞，证实了其他研究的结果，即手术交感神经切除术后肌肉血流无变化。
