环磷酸腺苷核糖作为一种钙动员信使。

Cyclic ADP ribose as a calcium-mobilizing messenger.

作者信息

Galione A, Churchill G C

机构信息

Department of Pharmacology, University of Oxford, UK.

出版信息

Sci STKE. 2000 Jul 18;2000(41):pe1. doi: 10.1126/stke.2000.41.pe1.

DOI:10.1126/stke.2000.41.pe1

PMID:11752598

Abstract

This Perspective by Galione and Churchill is one in a series on intracellular calcium release mechanisms. The authors review the evidence for cyclic adenosine diphosphate ribose (cADPR) being a second messenger involved in regulating intracellular calcium. In addition, the physiological stimuli and responses mediated by cADPR are discussed. The Perspective is accompanied by a movie showing a calcium wave triggered by cADPR.

摘要

加廖内和丘吉尔撰写的这篇《观点》是关于细胞内钙释放机制系列文章中的一篇。作者回顾了环磷酸腺苷二磷酸核糖（cADPR）作为参与调节细胞内钙的第二信使的证据。此外，还讨论了由cADPR介导的生理刺激和反应。这篇《观点》还配有一段展示由cADPR触发的钙波的视频。