Gough N R
American Association for the Advancement of Science, Science's Signal Transduction Knowledge Environment, Washington, DC, USA.
Sci STKE. 2001 Apr 3;2001(76):pe1. doi: 10.1126/stke.2001.76.pe1.
Meeting information: AAAS 2001 Annual Meeting and Science Innovation Exposition, San Francisco, California, February 15 through 20, 2001. Science's STKE sponsored a symposium at the AAAS Annual Meeting in February 2001. Five speakers addressed the signaling pathways that are modified in wide-ranging pathologies including inflammation, impotence, diabetes, obesity, and cancer. The molecular targets of signaling pathways included cell surface molecules, such as the G protein-coupled receptors (GPCRs) and receptor tyrosine kinases, and intracellular signaling components, such as phosphodiesterases (PDEs) and components of the small guanosine triphosphatase (GTPase) Ras signaling pathway. Analysis of the therapeutic strategies to impinge on these various pathways provides insight into both the potential of signaling pathways as relevant drug targets and the possible pitfalls that make complex signaling networks unpredictably difficult targets for such manipulation.
美国科学促进会2001年年会暨科技创新博览会，加利福尼亚州旧金山，2001年2月15日至20日。《科学》旗下的《科学信号》于2001年2月在美国科学促进会年会上主办了一场专题研讨会。五位演讲者探讨了在包括炎症、阳痿、糖尿病、肥胖症和癌症等多种病症中发生改变的信号通路。信号通路的分子靶点包括细胞表面分子，如G蛋白偶联受体（GPCRs）和受体酪氨酸激酶，以及细胞内信号传导成分，如磷酸二酯酶（PDEs）和小GTP酶（GTPase）Ras信号通路的成分。对作用于这些不同通路的治疗策略的分析，有助于深入了解信号通路作为相关药物靶点的潜力，以及使复杂信号网络成为难以预测的操控靶点的潜在陷阱。
