人乳头瘤病毒E6蛋白及其在恶性进展中的作用。
The human papillomavirus E6 protein and its contribution to malignant progression.
作者信息
Mantovani F, Banks L
机构信息
International Centre for Genetic Engineering and Biotechnology Padriciano 99, I-34012 Trieste, Italy.
出版信息
Oncogene. 2001 Nov 26;20(54):7874-87. doi: 10.1038/sj.onc.1204869.
The human papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to the development of human malignancy many laboratories have focused their attention on identifying the cellular proteins with which E6 interacts. In this review we discuss these interactions in the light of their respective contributions to the malignant progression of HPV transformed cells.
人乳头瘤病毒（HPV）E6蛋白是该病毒编码的三种癌蛋白之一。长期以来，它一直被认为是一种强效癌基因，并且与导致病毒感染细胞发生恶性转化的事件密切相关。为了了解E6促成人类恶性肿瘤发展的机制，许多实验室将注意力集中在鉴定与E6相互作用的细胞蛋白上。在这篇综述中，我们根据它们对HPV转化细胞恶性进展的各自贡献来讨论这些相互作用。
Zotero 插件