人乳头瘤病毒E7癌蛋白的生物学活性和分子靶点。

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein.

作者信息

Münger K, Basile J R, Duensing S, Eichten A, Gonzalez S L, Grace M, Zacny V L

机构信息

Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Oncogene. 2001 Nov 26;20(54):7888-98. doi: 10.1038/sj.onc.1204860.

DOI:10.1038/sj.onc.1204860

PMID:11753671

Abstract

The human papillomavirus (HPV) E7 protein is one of only two viral proteins that remain expressed in HPV-associated human cancers. HPV E7 proteins share structural and functional similarities with oncoproteins encoded by other small DNA tumor viruses such as adenovirus E1A and SV40 large tumor antigen. The HPV E7 protein plays an important role in the viral life cycle by subverting the tight link between cellular differentiation and proliferation in normal epithelium, thus allowing the virus to replicate in differentiating epithelial cells that would have normally withdrawn from the cell division cycle. The transforming activities of E7 largely reflect this important function.

摘要

人乳头瘤病毒（HPV）E7蛋白是仅有的两种在HPV相关人类癌症中仍持续表达的病毒蛋白之一。HPV E7蛋白与其他小型DNA肿瘤病毒（如腺病毒E1A和SV40大肿瘤抗原）编码的癌蛋白在结构和功能上具有相似性。HPV E7蛋白通过破坏正常上皮细胞中细胞分化与增殖之间的紧密联系，在病毒生命周期中发挥重要作用，从而使病毒能够在通常已退出细胞分裂周期的分化上皮细胞中进行复制。E7的转化活性在很大程度上反映了这一重要功能。