Wiltshire Steven, Frayling Timothy M, Hattersley Andrew T, Hitman Graham A, Walker Mark, Levy Jonathan C, O'Rahilly Stephen, Groves Christopher J, Menzel Stephan, Cardon Lon R, McCarthy Mark I
Imperial College Genetics and Genomics Research Institute and Division of Medicine, Imperial College, London, United Kingdom.
Am J Hum Genet. 2002 Feb;70(2):543-6. doi: 10.1086/338760. Epub 2001 Dec 20.
We have analyzed data from 573 pedigrees from the United Kingdom for evidence for linkage to loci influencing adult stature. Our data set comprised 1,214 diabetic and 163 nondiabetic siblings for whom height data were available. We used variance-components analysis implemented in GENEHUNTER 2 and a modification of the Haseman-Elston regression method, HE-COM. We found evidence for a locus on 3p26 (LOD score 3.17) influencing height in this adult sample, with less-significant evidence for loci on chromosomes 7, 10, 15, 17, 19, and 20. Our findings extend similar recent studies in Scandinavian and Quebecois populations, adding further evidence that height is indeed under the control of multiple genes.
我们分析了来自英国的573个家系的数据,以寻找与影响成人身高的基因座连锁的证据。我们的数据集包括1214名糖尿病患者和163名非糖尿病患者的兄弟姐妹,他们都有身高数据。我们使用了GENEHUNTER 2中实现的方差成分分析以及对Haseman-Elston回归方法(HE-COM)的一种改进。我们发现,在这个成人样本中,3p26上的一个基因座(LOD分数为3.17)影响身高,而在7号、10号、15号、17号、19号和20号染色体上的基因座的证据则不太显著。我们的研究结果扩展了最近在斯堪的纳维亚和魁北克人群中的类似研究,进一步证明身高确实受多个基因的控制。