宿主抵御沙门氏菌过程中的细胞因子
Cytokines in host defense against Salmonella.
作者信息
Eckmann L, Kagnoff M F
机构信息
Department of Medicine 0623D, Laboratory of Mucosal Immunology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA.
出版信息
Microbes Infect. 2001 Nov-Dec;3(14-15):1191-200. doi: 10.1016/s1286-4579(01)01479-4.
Cytokines are key communication molecules between host cells in the defense against the enteric pathogen, Salmonella. Infection with Salmonella induces expression of multiple chemokines and proinflammatory cytokines in cultured intestinal epithelial cells and macrophages. In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella.
细胞因子是宿主细胞之间在抵御肠道病原体沙门氏菌过程中的关键通讯分子。沙门氏菌感染可诱导培养的肠道上皮细胞和巨噬细胞中多种趋化因子和促炎细胞因子的表达。在动物模型中，已表明IL-1α、TNFα、IFN-γ、IL-12、IL-18和IL-15具有保护作用，而IL-4和IL-10则抑制宿主对沙门氏菌的防御。
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