Levinskas G J
Environ Health Perspect. 1975 Jun;11:203-7. doi: 10.1289/ehp.7511203.
There is neither a prescribed format nor a rigid sequence of testing to follow for the assessment of health and environmental effects of chemicals. Conventional animal toxicity tests plus medical surveillance and monitoring of exposed human populations will provide knowledge of the biological effects of chemicals and assurance that they can be handled safely. Useful information also can be derived from other test procedures. These include extraction studies to measure the amounts of additives which can leach from polymers, toxicity tests using aquatic organisms and birds, and determination of the biodegradability of materials and their potential for accumulation and magnification in biological systems. Current concern over pyrolysis products of polymers points up the need for defining the variables involved and development of test procedures by which meaningful evaluations of potential health hazards can be made.
对于化学品健康和环境影响的评估,既没有规定的格式,也没有严格的测试顺序可循。传统的动物毒性试验加上对接触化学品的人群进行医学监测,将提供有关化学品生物效应的知识,并确保它们能够安全处理。其他测试程序也能提供有用信息。这些包括测量聚合物中可浸出添加剂数量的萃取研究、使用水生生物和鸟类的毒性试验,以及测定材料的生物降解性及其在生物系统中的积累和放大潜力。目前对聚合物热解产物的关注凸显了定义相关变量以及开发测试程序的必要性,通过这些测试程序可以对潜在健康危害进行有意义的评估。