D'Souza D W, Vakil U K, Sreenivasan A
Environ Physiol Biochem. 1975;5(4):217-25.
The effects of whole-body X-irradiation on vitamin B12-protein complex formation in gastric juice after oral administration of [57Co]-B12 have been studied. Two proteins with B12-binding activity have been isolated by gel filtration from gastric juice. 57Co-activity, recovered from B12-protein complex in gastric juice, is found to be about 30% less in the X-irradiated rat. In serum, vitamin B12 is mainly associated with alpha1-globulin. Radioactivity distribution in serum globulins after intraperitoneal injection of [57Co]-B12 was similar in control and X-irradiated rats.
研究了全身X射线照射对口服[57Co]-维生素B12后胃液中维生素B12-蛋白质复合物形成的影响。通过凝胶过滤从胃液中分离出两种具有维生素B12结合活性的蛋白质。发现从X射线照射大鼠的胃液中维生素B12-蛋白质复合物回收的57Co活性比未照射大鼠低约30%。在血清中，维生素B12主要与α1球蛋白结合。腹腔注射[57Co]-维生素B12后，对照大鼠和X射线照射大鼠血清球蛋白中的放射性分布相似。
