Von der Lippe G, Andersen K J, Schjönsby H
Scand J Gastroenterol. 1976;11(8):807-12.
Determination of vitamin-B12-binding capacity and gel filtration of human pancreatic juice (HPJ) and rat pancreatic juice (RPJ) demonstrated a vitamin B12 binder different from gastric intrinsic factor (IF). The results also indicated the presence of the pancreatic B12 binding in human duodenal juice. The binder in RPJ had no significant effect on the uptake of 57CoB12 and 57CoB12 bound to rat IF by perfused rat intestinal segments (p greater than 0.5; p greater than 0.1). The binder in HPJ had no effect on the uptake of unbound 57CoB12 or 57CoB12 bound to human IF by guinea pig intestinal brush borders (p greater than 0.05; p greater than 0.1). The results indicate that the pancreatic vitamin B12 binder does not influence the intestinal uptake of vitamin B12.
对人胰液（HPJ）和大鼠胰液（RPJ）中维生素B12结合能力的测定以及凝胶过滤显示，存在一种不同于胃内因子（IF）的维生素B12结合蛋白。结果还表明人十二指肠液中存在胰腺维生素B12结合蛋白。RPJ中的结合蛋白对灌注的大鼠肠段摄取57CoB12以及与大鼠IF结合的57CoB12没有显著影响（p>0.5；p>0.1）。HPJ中的结合蛋白对豚鼠肠刷状缘摄取未结合的57CoB12或与人IF结合的57CoB12没有影响（p>0.05；p>0.1）。结果表明胰腺维生素B12结合蛋白不影响维生素B12的肠道摄取。
