Moreland A F, Gaskin J M, Schimpff R D, Woodard J C, Olson G A
Teratology. 1979 Aug;20(1):53-64. doi: 10.1002/tera.1420200109.
Pregnant Rhesus monkeys were infected via instillation of influenza, mumps and western equine encephalomyelitis viruses respectively into the amniotic sacs at approximately 90 days gestation to determine if fetal infections would occur. Virus was recovered from fetal tissues after seven days in 100% of the exposed animals. Thus, the viruses are capable of causing fetal infection. Rhesus monkey fetuses were inoculated with influenza, mumps and WEE viruses by the direct intracerebral route at approximately 90 days gestation to determine possible teratogenicity of the viruses. influenza virus caused no malformations or measurable fetal effects. Mumps virus resulted in significant fetal mortality. WEE virus resulted in a 100% incidence of encephalitis and hydrocephalus. Thus, mumps and WEE viruses are teratogens in primates and are potential teratogens of man.
在妊娠约90天时，分别通过向羊膜腔内滴注流感病毒、腮腺炎病毒和西部马脑炎病毒，对怀孕的恒河猴进行感染，以确定是否会发生胎儿感染。在暴露的动物中，100%的动物在7天后从胎儿组织中分离出病毒。因此，这些病毒能够引起胎儿感染。在妊娠约90天时，通过直接脑内途径给恒河猴胎儿接种流感病毒、腮腺炎病毒和西部马脑炎病毒，以确定这些病毒可能的致畸性。流感病毒未引起畸形或可测量的胎儿效应。腮腺炎病毒导致显著的胎儿死亡。西部马脑炎病毒导致100%的脑炎和脑积水发生率。因此，腮腺炎病毒和西部马脑炎病毒是灵长类动物的致畸原，也是人类潜在的致畸原。
