Moreland A F, Schimpff R D, Gaskin J M
Teratology. 1979 Aug;20(1):65-74. doi: 10.1002/tera.1420200110.
Pregnant Rhesus monkeys were infected via installation of Western Equine Encephalomyelitis (WEE) vaccine virus into the amniotic sacs at 50 and 80 days gestation to determine if the resulting infections would produce fetal mortality or fetal malformations, particularly within the central nervous system. Of those receiving virus at 50 days gestation, 13 of 18 fetuses were aborted or dead in utero at time of Caesarean section; 2 of 18 were malformed (hydrocephalus and polyarthrosis); and 3 of 18 were anatomically normal. Of those receiving virus at 80 days gestation four of eight fetuses were aborted or dead in utero at time of Caesarean section, one of eight was malformed (hydrocephalus) and three of eight were anatomically normal. Three of three controls receiving neutralized virus at each gestational age were anatomically normal. Fetal WEE vaccine virus infection significantly increased fetal mortality and resulted in a significant incidence of fetal malformations.
在妊娠50天和80天时，通过向羊膜囊接种西部马脑炎（WEE）疫苗病毒，感染怀孕的恒河猴，以确定由此产生的感染是否会导致胎儿死亡或胎儿畸形，特别是中枢神经系统的畸形。在妊娠50天接受病毒接种的猴子中，18只胎儿中有13只在剖腹产时流产或死于子宫内；18只中有2只畸形（脑积水和多关节病）；18只中有3只解剖结构正常。在妊娠80天接受病毒接种的猴子中，8只胎儿中有4只在剖腹产时流产或死于子宫内，8只中有1只畸形（脑积水），8只中有3只解剖结构正常。在每个胎龄接受中和病毒的3只对照猴子解剖结构均正常。胎儿感染WEE疫苗病毒显著增加了胎儿死亡率，并导致胎儿畸形的发生率显著升高。
