西部马脑炎病毒对猕猴胎儿神经系统的致畸作用。
Teratological effects of western equine encephalitis virus on the fetal nervous system of Macaca mulatta.
作者信息
London W T, Levitt N H, Altshuler G, Curfman B L, Kent S G, Palmer A E, Sever J L, Houff S A
出版信息
Teratology. 1982 Feb;25(1):71-9. doi: 10.1002/tera.1420250110.
PMID:7064113
Abstract
Fetal rhesus monkeys were inoculated intracerebrally with an attenuated strain of western equine encephalitis virus. All animals developed microcephaly. Twelve of sixteen monkeys developed ex vacuo hydrocephalus. All virus inoculated fetuses developed WEE virus antibody. Virus could not be recovered at the time of delivery. Monkeys with the highest WEE antibody titers showed the greatest degree of hydrocephalus.
摘要
将恒河猴胎儿脑内接种西部马脑炎病毒减毒株。所有动物均出现小头畸形。16只猴子中有12只出现代偿性脑积水。所有接种病毒的胎儿均产生了西部马脑炎病毒抗体。分娩时未检测到病毒。西部马脑炎病毒抗体滴度最高的猴子脑积水程度最严重。
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