Taupitz Matthias, Schnorr Jörg, Wagner Susanne, Abramjuk Claudia, Pilgrimm Herbert, Kivelitz Dietmar, Schink Tania, Hansel Jörg, Laub Gerhard, Hünigen Hanna, Hamm Bernd
Department of Radiology, Institute for Medical Biometry, Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany.
Radiology. 2002 Jan;222(1):120-6. doi: 10.1148/radiol.2221001452.
To evaluate the signal-enhancing characteristics of monomer-coated very small superparamagnetic iron oxide (SPIO) particles used as a blood pool contrast medium for magnetic resonance (MR) angiography in the coronary arteries.
The particles used in this study were coated with citrate as the monomer (VSOP-C91). The particles have a total diameter of 7 nm and show the following relaxivities at 0.47 T: T1, 19 L/mmol. sec(-1); T2, 29 L/mmol. sec(-1). Fifteen cardiac MR examinations were performed at 1.5 T in five pigs. Images were acquired from immediately to 35 minutes (equilibrium phase) after intravenous injection of gadopentetate dimeglumine, gadobenate dimeglumine, and the very small SPIO particles (n = 5 for each substance).
Immediately after administration of gadopentetate dimeglumine, gadobenate dimeglumine, and the very small SPIO particles, respectively, increases in the signal-to-noise ratio in blood were 94%, 103%, and 102% and in myocardium were 83%, 83%, and 29% (P <.05, very small SPIO particles versus the low-molecular-weight gadolinium-based compounds). Differences in the blood-to-myocardium contrast-to-noise ratio and visualization of the coronary arteries and their branches were also significant.
VSOP-C91 significantly improves visualization of the coronary arteries at MR angiography from immediately to 35 minutes after injection.
评估用作冠状动脉磁共振（MR）血管造影血池造影剂的单体包被的超小超顺磁性氧化铁（SPIO）颗粒的信号增强特性。
本研究中使用的颗粒用柠檬酸盐作为单体进行包被（VSOP-C91）。这些颗粒的总直径为7 nm，在0.47 T时显示出以下弛豫率：T1为19 L/mmol·秒-1；T2为29 L/mmol·秒-1。在5头猪身上于1.5 T进行了15次心脏MR检查。在静脉注射钆喷酸葡胺、钆贝葡胺和超小SPIO颗粒后，立即至35分钟（平衡期）采集图像（每种物质n = 5）。
分别在注射钆喷酸葡胺、钆贝葡胺和超小SPIO颗粒后，血液中的信噪比立即增加，分别为94%、103%和102%，心肌中的信噪比分别为83%、83%和29%（P <.05，超小SPIO颗粒与低分子量钆基化合物相比）。血液与心肌的对比噪声比以及冠状动脉及其分支的可视化差异也很显著。
VSOP-C91在注射后立即至35分钟的MR血管造影中显著改善了冠状动脉的可视化。
