Matuszewski L, Tombach B, Heindel W, Bremer C
Institut für Klinische Radiologie, Universitätsklinikum Münster.
Radiologe. 2007 Jan;47(1):34-42. doi: 10.1007/s00117-006-1451-y.
Superparamagnetic iron oxide (SPIO) contrast agents, clinically established for high resolution magnetic resonance imaging of reticuloendothelial system containing anatomical structures, can additionally be exploited for the non-invasive characterization and quantification of pathology down to the molecular level. In this context, SPIOs can be applied for non-invasive cell tracking, quantification of tissue perfusion and target specific imaging, as well as for the detection of gene expression. This article provides an overview of new applications for clinically approved iron oxides as well of new, modified SPIO contrast agents for parametric and molecular imaging.
超顺磁性氧化铁（SPIO）造影剂在临床上已用于含网状内皮系统解剖结构的高分辨率磁共振成像，此外还可用于在分子水平对病理状况进行无创性特征描述和定量分析。在此背景下，SPIO可用于无创性细胞追踪、组织灌注定量和靶向特异性成像，以及基因表达检测。本文概述了临床批准的氧化铁的新应用以及用于参数成像和分子成像的新型改良SPIO造影剂。
