Frayn K N
Eur J Clin Invest. 1975 Jul 29;5(4):331-7. doi: 10.1111/j.1365-2362.1975.tb00462.x.
Both insulin resistance and impairment of insulin secretion are know to occur in man after injury. The relative importance of these effects was studied in rats 2 h after a non-lethal 20 percent dorsal scald. No impairment of insulin secretion was found after this injury. Concentrations of both blood glucose and plasma insulin were elevated in scalded rats. Scalded rats responded to intravenous glucose injection (1-0 g/kg) with a further rise in plasma insulin concentration, which remained normal for the prevailing blood glucose concentration. However, marked impairment of glucose tolerance was observed, indicating the presence of insulin resistance. After intravenous insulin injection (1-0 U/kg) the initial rate coefficient for fall of blood glucose concentration was significantly lower (p less than 0-02) in scalded (mean 3-9 percent min.(-1) than in control rats (mean 6-3 percent min.(-1). The minimum in blood glucose concentration after insulin injection was reached at 10 min. in control rats, but not until 60 min. after injection in scalded rats. This difference was due to a delay in compensation for the hypoglycaemia in the scalded rats, since the rate of disappearance of insulin measured by injection of a tracer of 125I-labelled bovine insulin was not decreased after this injury. It was concluded that the impairment of glucose utilization in scalded rats (Heath and Corney, 1973) is due to decreased sensitivity to insulin rather than to suppression of insulin release.
已知人体受伤后会出现胰岛素抵抗和胰岛素分泌受损的情况。在大鼠遭受20%非致命性背部烫伤2小时后，对这些影响的相对重要性进行了研究。此次受伤后未发现胰岛素分泌受损。烫伤大鼠的血糖和血浆胰岛素浓度均升高。烫伤大鼠对静脉注射葡萄糖（1.0 g/kg）的反应是血浆胰岛素浓度进一步升高，对于当时的血糖浓度而言，该浓度仍保持正常。然而，观察到明显的葡萄糖耐量受损，表明存在胰岛素抵抗。静脉注射胰岛素（1.0 U/kg）后，烫伤大鼠血糖浓度下降的初始速率系数（平均3.9%每分钟）显著低于对照大鼠（平均6.3%每分钟）（p<0.02）。对照大鼠在注射胰岛素后10分钟达到血糖浓度最低点，而烫伤大鼠直到注射后60分钟才达到。这种差异是由于烫伤大鼠对低血糖的代偿延迟，因为注射125I标记的牛胰岛素示踪剂测定的胰岛素消失速率在此次受伤后并未降低。得出的结论是，烫伤大鼠葡萄糖利用受损（希思和科尼，1973年）是由于对胰岛素的敏感性降低，而非胰岛素释放受到抑制。
