Frayn K N
Br J Exp Pathol. 1976 Jun;57(3):316-20.
The effects on insulin secretion of injuries of differing severity have been studied in the rat. The injuries used were dorsal scalds to 20% and 40% of the body surface area, and a 4-h period of bilateral hind-limb ischaemia. These injuries resulted in 48 h mortality rates of 0/10, 7/10 and 5/10 respectively. Rats were studied 1-5-2 h after scalding or removal of tourniquets. The blood glucose concentration was markedly raised after all these injuries, and the plasma insulin concentration was also raised, so that the insulin to glucose ratio in any group did not differ significantly from that in non-injured controls. Injection of glucose (0-5 g/kg i.v.) induced a rise in insulin concentration in all groups, although the insulin to glucose ratio after the lethal 40% scald was lower than in control rats. It was concluded that in the rat normal insulin secretion is maintained even after lethal injuries, although some suppression of the insulin response to exogenous glucose may occur. Insulin resistance is more important in the rat than impairment of insulin secretion even at an early stage after injury.
在大鼠中研究了不同严重程度损伤对胰岛素分泌的影响。所采用的损伤包括占体表面积20%和40%的背部烫伤，以及4小时的双侧后肢缺血。这些损伤导致的48小时死亡率分别为0/10、7/10和5/10。在烫伤或松开止血带后1-5-2小时对大鼠进行研究。所有这些损伤后血糖浓度均显著升高，血浆胰岛素浓度也升高，因此任何一组的胰岛素与葡萄糖比值与未受伤对照组相比无显著差异。静脉注射葡萄糖（0-5 g/kg）可使所有组的胰岛素浓度升高，尽管40%致死性烫伤后胰岛素与葡萄糖比值低于对照大鼠。得出的结论是，在大鼠中，即使遭受致死性损伤，正常胰岛素分泌仍得以维持，尽管对外源性葡萄糖的胰岛素反应可能会有一些抑制。在大鼠中，即使在损伤后的早期阶段，胰岛素抵抗比胰岛素分泌受损更为重要。
