Goldstein J M, Barnett A, Malick J B
Eur J Pharmacol. 1975 Aug;33(1):183-8. doi: 10.1016/0014-2999(75)90154-5.
The effect of anti-parkinson drugs on reserpine-induced rigidity was examined using a technique which measured rigidity by hind limb palpation. Centrally acting dopaminergic and anti-cholinergic drugs were able to antagonize reserpine-induced rigidity, whereas peripherally acting drugs had no effect. Results are discussed in terms of possible modes of action. Relative potencies of the drugs studied in this model were well correlated with the dose ranges of clinically established anti-parkinson drugs. It is concluded that measurement of reserpine-induced rigidity by hind limb palpation is a rapid and sensitive technique to evaluate potential anti-parkinson drugs.
采用通过后肢触诊测量僵直的技术，研究了抗帕金森病药物对利血平诱导的僵直的影响。中枢作用的多巴胺能药物和抗胆碱能药物能够拮抗利血平诱导的僵直，而外周作用的药物则无作用。根据可能的作用模式对结果进行了讨论。在该模型中所研究药物的相对效价与临床常用抗帕金森病药物的剂量范围具有良好的相关性。得出结论，通过后肢触诊测量利血平诱导的僵直是一种快速且灵敏的评估潜在抗帕金森病药物的技术。
