Johnels B
Pharmacol Biochem Behav. 1983 Sep;19(3):463-70. doi: 10.1016/0091-3057(83)90121-1.
A study of the pathophysiological mechanisms of reserpine rigidity with the aid of a mechanographic method for the quantification of muscle tone. Apomorphine was used as a test substance to reduce reserpine rigidity by stimulation of dopamine receptors. Some experiments were made with additional drug treatment in an attempt to ascertain the dopaminergic specificity of the test. Apomorphine injected bilaterally to the corpus striatum has been shown to counteract the rigidity [6]. Microinjections of reserpine to corpus striatum induced rigidity with dominance in the hindleg ipsilateral to the side of injection. This rigidity was reduced by subcutaneous apomorphine. The effect of subcutaneous apomorphine on the rigidity was blocked by prior microinjection of trifluoperazine to the corpus striatum. Injections to nucleus accumbens were ineffective in all these respects. It is concluded that reserpine induces rigidity mainly by interference with the dopamine transmission in the corpus striatum.
借助一种用于量化肌张力的肌动描记法对利血平致僵的病理生理机制进行的研究。阿扑吗啡用作测试物质，通过刺激多巴胺受体来减轻利血平致僵。进行了一些额外药物治疗的实验，试图确定该测试的多巴胺能特异性。已证明双侧注射到纹状体的阿扑吗啡可对抗僵直[6]。向纹状体微量注射利血平会诱发僵直，且注射侧后肢更为明显。皮下注射阿扑吗啡可减轻这种僵直。预先向纹状体微量注射三氟拉嗪可阻断皮下阿扑吗啡对僵直的作用。在所有这些方面，向伏隔核注射均无效。得出的结论是，利血平主要通过干扰纹状体中的多巴胺传递来诱发僵直。
