Benes J, Hrusovský J, Proksová M
Vet Med (Praha). 1979 Oct;24(10):623-32.
Sheep were studied for the possibility of treatment after parenteral (intramuscular) intoxication with EDMM (methylthiophosphorous acid O-ethyl-S-2-dimethylamino-ethylester) and with EDIM (methylthiophosphorous acid O-ethyl-S-2-diisopropyl-aminoethylester). In both cases of intoxication, the therapy was based on a system of an anticholinergic and cholinesterase reactivator administered singly at a time of the maximum development of the clinical signs of poisoning and maximum inhibition of both erythrocytic (AChE, E.C.3.1.1.7.) and plasma (BChE, E.C.3.1.1.8.) cholinesterase. The optimum therapeutic system requires the administration of 20.0 mg atropine s. c. pro toto and 10.0 mg trimedoxim per kg 1. w. i. v. In both cases of poisoning with doses = LD50 in i. m. administration, the mentioned system was actually positive. In a single administration irrespective of the doses of the used drugs, the system does not guarantee survival after ingestion of anticholinesterasic doses above LD50.
研究了绵羊经肠胃外（肌肉内）摄入乙硫磷（O-乙基-S-2-二甲基氨基乙酯甲基硫代磷酸酯）和乙拌磷（O-乙基-S-2-二异丙基氨基乙酯甲基硫代磷酸酯）中毒后进行治疗的可能性。在这两种中毒情况下，治疗均基于一种抗胆碱能和胆碱酯酶复活剂系统，在中毒临床症状发展到最严重且红细胞（乙酰胆碱酯酶，E.C.3.1.1.7.）和血浆（丁酰胆碱酯酶，E.C.3.1.1.8.）胆碱酯酶受到最大抑制时单独给药。最佳治疗方案要求每千克体重皮下注射20.0毫克阿托品和静脉注射10.0毫克三甲肟。在两种肌肉注射剂量等于半数致死量（LD50）的中毒情况下，上述治疗方案实际效果良好。无论所用药物剂量如何，单次给药时，该方案无法保证摄入高于半数致死量的抗胆碱酯酶剂量后绵羊存活。
