Benes J, Proksová M, Hrusovský J
Vet Med (Praha). 1976 Apr;21(4):237-49.
A single application of a mixture of cholinolytic and reactivator of cholinesterase (TMB-4 compos. SPOFA) administered intravenously in the dose of 10.0 mg of trimedoxim per kg of live weight to sheep for 60 minutes after an intramuscular intoxication with O-ethyl S-(2-dimethylaminoethyl) methyl phosphonothioate (EDMM) in the dose of 0.00835 mg per kg of live weight (i.m. LD50, 2h) produces an immediate clinical effect. The reactivation of the erythrocytary acetyl cholinesterase (AChE, E.C.3.1.1.7.) examined in 15 minutes after the administration of the antidotal mixture is almost 100 p.c., the reactivation of the plasmatic butyryl cholin esterase (ChE, E.C.3.1.1.8.) approx. from 70 to 80 p. c. Restitution ad integrum occurred not later than in 14 days after the intoxication.
对体重每千克静脉注射剂量为10.0毫克三甲双酮肟的胆碱能阻断剂和胆碱酯酶复活剂混合物（TMB - 4成分，SPOFA），在体重每千克肌肉注射0.00835毫克O - 乙基S - （2 - 二甲基氨基乙基）甲基硫代磷酸酯（EDMM）（肌肉注射半数致死量，2小时）中毒60分钟后的绵羊进行单次给药，可产生即时临床效果。在给予解毒剂混合物15分钟后检测的红细胞乙酰胆碱酯酶（AChE，E.C.3.1.1.7.）的复活率几乎为100%，血浆丁酰胆碱酯酶（ChE，E.C.3.1.1.8.）的复活率约为70%至80%。中毒后不迟于14天完全恢复。
