Bellón J M, García-Honduvilla N, Jurado F, García-Carranza A, García-Moreno F, Martín A C, Buján J
Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcalá, Madrid, Spain.
Eur J Surg. 2001 Sep;167(9):666-71. doi: 10.1080/11024150152619291.
To compare the behaviour of two composite biomaterials in rabbit peritoneum.
Animal study.
Faculty of Medicine, University of Alcalá, Spain.
14 white New Zealand white rabbits divided into 2 groups of 7 each.
Defects (7 x 5 cm) involving all the layers of the abdominal wall were created and repaired using Parietex Composite or Vypro prostheses. Fourteen days after implantation, prosthetic specimens were examined by microscopy, and morphometric and biomechanical analysis.
Infection, healing, development of adhesions, and histological appearance of the interface.
Firm adhesions were detected after the implant of Vypro while adhesion were loose in the Parietex group. The mean (SD) prosthetic surface area covered by adhesions was significantly greater in the Vypro group 22.3 (2.8) compared with 0.2 (0.02), p <0.01). The neoperitoneum formed after the implant of Parietex was well-organised and homogeneous and covered by a typical mesothelium, while in the Vypro it was disorganised, with a rough texture composed of prosthetic filaments and nodes. The neoperitonum was thicker in the Parietex group 154.0 (5.4) compared with 50.8 (2.3), p <0.05) while higher biomechanical resistance values were recorded in the Vypro group 30.4 (1.9) compared with 15.0 (2.73), p <0.05).
While both biomaterials integrated well with tissue, Parietex behaved better at the peritoneal interface.
比较两种复合生物材料在兔腹膜中的表现。
动物研究。
西班牙阿尔卡拉大学医学院。
14只新西兰白兔，分为2组，每组7只。
制造涉及腹壁各层的缺损（7×5厘米），并用Parietex复合材料或Vypro假体进行修复。植入后14天，通过显微镜检查、形态计量学和生物力学分析对假体标本进行检查。
感染、愈合、粘连形成情况以及界面的组织学外观。
植入Vypro后检测到牢固粘连，而Parietex组的粘连较松散。Vypro组粘连覆盖的平均（标准差）假体表面积显著大于Parietex组，分别为22.3（2.8）和0.2（0.02），p<0.01）。植入Parietex后形成的新腹膜组织良好且均匀，覆盖有典型的间皮，而Vypro组的新腹膜则杂乱无章，质地粗糙，由假体细丝和结节组成。Parietex组的新腹膜更厚，为154.0（5.4），而Vypro组为50.8（2.3），p<0.05）；Vypro组的生物力学阻力值更高，为30.4（1.9），而Parietex组为15.0（2.73），p<0.05）。
虽然两种生物材料都能与组织良好整合，但Parietex在腹膜界面的表现更好。
