Hudson T A, Bragg J A, Lin D C, DeWeerth S P
School of Electrical and Computer Engineering, Laboratory for Neuroengineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.
IEEE Trans Biomed Eng. 2001 Dec;48(12):1471-9. doi: 10.1109/10.966606.
We have developed an integrated circuit to simulate the mechanical behavior demonstrated by sarcomeres found in skeletal muscle. The circuit is based upon the mathematical description of the attachment and detachment dynamics of crossbridge populations and the force generated by the crossbridges, originally formulated by A. F. Huxley. We describe the process of designing the circuit model from the mathematical model, present the sarcomere circuit implementation, and demonstrate the transient and steady-state behaviors that the fabricated circuit produces. Comparison of our results to published mechanical behavior of skeletal muscle shows qualitative similarities. We conclude that the circuit muscle model exhibits the potential for real-time simulation of muscle contractions and could be used to give engineered systems muscle-like properties.
我们开发了一种集成电路，用于模拟骨骼肌中肌节所表现出的力学行为。该电路基于对横桥群体附着和解离动力学以及横桥产生的力的数学描述，最初由A. F. 赫胥黎提出。我们描述了从数学模型设计电路模型的过程，展示了肌节电路的实现，并演示了所制造电路产生的瞬态和稳态行为。将我们的结果与已发表的骨骼肌力学行为进行比较，显示出定性的相似性。我们得出结论，电路肌肉模型具有实时模拟肌肉收缩的潜力，可用于赋予工程系统类似肌肉的特性。
