Ertenli I, Kiraz S, Calgüneri M, Celik I, Erman M, Haznedaroglu I C, Kirazli S
Department of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.
Clin Exp Rheumatol. 2001 Sep-Oct;19(5 Suppl 24):S37-41.
To investigate the synovial fluid levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), IL-1 receptor antagonist (IL-1ra), soluble IL-2 receptor (sIL-2r) and IL-8 in patients with Behçet's disease (BD) and to compare them to levels in rheumatoid arthritis (RA), and osteoarthritis (OA).
The cytokine levels of BD (n = 14), RA (n = 15) and OA (n = 15) patients were assessed by enzyme-linked immunosorbent method.
Median synovial IL-1 beta and TNF-alpha levels were higher in RA compared to BD and OA patients. IL-1 beta levels were also higher in BD than OA whereas TNF levels were similar in these two groups. IL-1ra and TGF-beta activity in BD were higher than OA but lower than RA. sIL-2r and IL-8 levels were increased in BD and RA in comparison to OA patients.
The arthritis of BD is non-erosive and accordingly, its synovial fluid contains lower levels of cytokines primarily involved in cartilage destruction, namely IL-1 beta and TNF-alpha, than RA. IL-1ra and TGF might serve as protective factors against erosion in the inflamed joints. High synovial fluid levels of sIL-2r and IL-8 probably reflect a non-specific inflammatory process.
研究白塞病（BD）患者滑液中白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、转化生长因子-β（TGF-β）、IL-1受体拮抗剂（IL-1ra）、可溶性IL-2受体（sIL-2r）和IL-8的水平，并与类风湿关节炎（RA）和骨关节炎（OA）患者的水平进行比较。
采用酶联免疫吸附法评估BD患者（n = 14）、RA患者（n = 15）和OA患者（n = 15）的细胞因子水平。
与BD和OA患者相比，RA患者滑液中IL-1β和TNF-α的中位数水平更高。BD患者的IL-1β水平也高于OA患者，而这两组的TNF水平相似。BD患者的IL-1ra和TGF-β活性高于OA患者，但低于RA患者。与OA患者相比，BD和RA患者的sIL-2r和IL-8水平升高。
BD相关性关节炎无侵蚀性，因此其滑液中主要参与软骨破坏的细胞因子（即IL-1β和TNF-α）水平低于RA。IL-1ra和TGF可能是炎症关节抗侵蚀的保护因子。滑液中高水平的sIL-2r和IL-8可能反映了一种非特异性炎症过程。
