Hano J, Bugajski J, Danek L
Arch Immunol Ther Exp (Warsz). 1976;24(4):507-24.
The effect of adrenergic blockade on gastric secretion altered by catecholamines was studied for 4 hr after injection in rats with chronic gastric fistulas. The alpha-adrenergic blockers phenoxybenzamine and phentolamine significantly inhibited the basal secretion of HCl and pepsin. Blockade of the beta-adrenergic receptors with propranolol did not change this secretion. Practolol in small doses slightly increased and in larger doses inhibited HCl out-put. Of the catecholamines, adrenaline and dopamine most markedly reduced HCl and pepsin secretion, while noradrenaline and isoprenaline had a weaker effect. Neither alpha- nor beta-adrenergic blockers prevented the inhibitory action of the catecholamines employed, but intensified the depression of the gastric secretion provoked by them. Adrenergic blockers inhibited secretion after catecholamines as well as basal secretion. This indicates that these two antagonistic groups of compounds act independently on the mechanism controlling gastric secretion. It is unlikely that this takes place indirectly through changes in the blood supply of the gastric mucosa.
在患有慢性胃瘘的大鼠中，研究了注射肾上腺素能阻滞剂对儿茶酚胺改变的胃分泌的影响，持续观察4小时。α-肾上腺素能阻滞剂酚苄明和酚妥拉明显著抑制了盐酸和胃蛋白酶的基础分泌。用普萘洛尔阻断β-肾上腺素能受体并未改变这种分泌。小剂量的普拉洛尔略有增加，大剂量时则抑制盐酸分泌。在儿茶酚胺中，肾上腺素和多巴胺最显著地减少了盐酸和胃蛋白酶的分泌，而去甲肾上腺素和异丙肾上腺素的作用较弱。α-和β-肾上腺素能阻滞剂均不能阻止所用儿茶酚胺的抑制作用，但会加剧它们所引起的胃分泌抑制。肾上腺素能阻滞剂抑制了儿茶酚胺作用后的分泌以及基础分泌。这表明这两类拮抗化合物对控制胃分泌的机制独立起作用。这种情况不太可能通过胃黏膜血液供应的变化间接发生。
