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嗜酸性胃肠炎:我们的近期经验:一种罕见疾病非典型起病的一年经验

Eosinophilic gastroenteritis: our recent experience: one-year experience of atypical onset of an uncommon disease.

作者信息

Redondo-Cerezo E, Cabello M J, González Y, Gómez M, García-Montero M, de Teresa J

机构信息

Servicio de Aparato Digestivo, Hospital Universitario Virgen de las Nieves, Granada, Spain.

出版信息

Scand J Gastroenterol. 2001 Dec;36(12):1358-60. doi: 10.1080/003655201317097254.

Abstract

Eosinophilic gastroenteritis is an unusual entity that is rarely found in daily clinical practise. Its aetiology is unknown and diagnosis can be made microscopically with evidence of massive eosinophilic infiltration in patients with chronic gastrointestinal symptoms, excluding entities that may cause such findings (parasitic infestation, medical therapy, inflammatory bowel disease, and so on). Allergic processes are usually associated and these normally respond well to steroids. We present our last year's experience of four women with eosinophilic gastroenteritis with an extraordinary atypical clinical onset. Two of the women presented with an acute abdomen and two with isolated colonic involvement. The management of acute abdomen avoiding surgery and a complete response with azathioprine are the outstanding variables that make our recent cases of special interest. Demographic variables were similar to others reported from our medium, with the exception of a higher incidence of women. Our cases suggest the wide spectrum of clinical presentations and show the high suspicion index needed for a diagnosis that is made by pathologists.

摘要

嗜酸性胃肠炎是一种不常见的疾病,在日常临床实践中很少见。其病因不明,可通过显微镜诊断,即在慢性胃肠道症状患者中发现大量嗜酸性粒细胞浸润,同时排除可能导致此类表现的疾病(寄生虫感染、药物治疗、炎症性肠病等)。过敏过程通常与之相关,且这些患者通常对类固醇治疗反应良好。我们介绍了去年诊治的四名患有嗜酸性胃肠炎且临床起病异常不典型的女性患者的经验。其中两名女性表现为急腹症,另外两名仅累及结肠。避免手术治疗急腹症以及使用硫唑嘌呤治疗后完全缓解是使我们近期病例特别引人关注的突出变量。除女性发病率较高外,人口统计学变量与我们地区报告的其他病例相似。我们的病例表明了临床表现的多样性,并显示出病理学家做出诊断所需的高度怀疑指数。

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