Whitaker I S, Gulati A, McDaid J O, Bugajska-Carr U, Arends M J
University of Cambridge, Cambridge, UK.
Eur J Gastroenterol Hepatol. 2004 Apr;16(4):407-9. doi: 10.1097/00042737-200404000-00007.
Eosinophilic gastroenteritis is a rare condition of unknown aetiology, first described by Kaijser in 1937. It is manifest by eosinophilic infiltration of the gastrointestinal tract and peripheral eosinophilia. Patients have various clinical presentations depending on the region of the gastrointestinal tract involved and the depth and extent of the bowel wall involvement. Whereas gastrointestinal obstruction associated with this condition is not uncommon, isolated biliary obstruction has only been reported twice. We present a case of eosinophilic gastroenteritis with involvement of the biliary tract causing ulceration, fibrosis and obstruction. Although a rare condition, we believe the diagnosis of eosinophilic gastroenteritis should be entertained in patients with gastrointestinal symptoms and a peripheral eosinophilia who have no evidence of parasitic infection, vasculitis or neoplasms.
嗜酸性粒细胞性胃肠炎是一种病因不明的罕见疾病,最早由凯伊泽于1937年描述。其表现为胃肠道嗜酸性粒细胞浸润和外周血嗜酸性粒细胞增多。根据胃肠道受累区域以及肠壁受累的深度和范围,患者有各种临床表现。虽然与这种疾病相关的胃肠道梗阻并不少见,但孤立性胆管梗阻仅报道过两例。我们报告一例嗜酸性粒细胞性胃肠炎累及胆道,导致溃疡、纤维化和梗阻的病例。尽管是罕见疾病,但我们认为,对于有胃肠道症状且外周血嗜酸性粒细胞增多、无寄生虫感染、血管炎或肿瘤证据的患者,应考虑嗜酸性粒细胞性胃肠炎的诊断。