Kuźmiński Andrzej, Rosada Tomasz, Przybyszewska Justyna, Ukleja-Sokołowska Natalia, Bartuzi Zbigniew
Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Department of Nutrition and Dietetics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Prz Gastroenterol. 2023;18(2):135-140. doi: 10.5114/pg.2022.118635. Epub 2022 Aug 9.
Treatment of eosinophilic gastroenteritis (EGE) is mainly empirical and is based on the assessment of symptom severity and the experience of clinicians. Patients with mild disease can be treated symptomatically, while patients with more severe symptoms or malabsorption symptoms require more aggressive therapy. So far, several therapeutic options have been proposed, including the following: dietary treatment, glucocorticosteroids, inhibitors of leukotriene receptors, mast cell stabilizers, immunomodulating drugs, and biological drugs. Unfortunately, there is still a lack of well-designed, prospective. and randomized clinical trials involving large groups of patients with EGE and assessing the effectiveness of individual treatments. More research is needed to compare the efficacy and safety profiles of the various treatments available, and to select the prognostic factors of relapse, which in turn will be extremely important in making decisions about the initial treatment phase and maintenance therapy.
嗜酸性粒细胞性胃肠炎（EGE）的治疗主要是经验性的，基于对症状严重程度的评估和临床医生的经验。轻症患者可进行对症治疗，而症状较重或有吸收不良症状的患者则需要更积极的治疗。到目前为止，已经提出了几种治疗选择，包括以下几种：饮食治疗、糖皮质激素、白三烯受体抑制剂、肥大细胞稳定剂、免疫调节药物和生物药物。不幸的是，仍然缺乏设计良好、前瞻性的、涉及大量EGE患者并评估个体治疗效果的随机临床试验。需要更多的研究来比较现有各种治疗方法的疗效和安全性，并选择复发的预后因素，这反过来对于决定初始治疗阶段和维持治疗将极其重要。
