印度马哈拉施特拉邦孟买耆那教人群中的HLA抗原分布情况。

HLA antigen distribution in Jain population from Mumbai, Maharashtra, India.

作者信息

Chhaya S U, Shankarkumar U

机构信息

Department of Transfusion Medicine, Tata Memorial Hospital, Mumbai, India.

出版信息

Indian J Med Res. 2001 Jul;114:25-9.

PMID:11762203

Abstract

BACKGROUND & OBJECTIVES: The Indian population is well known for its genetic diversity. Among the numerous endogamous communities, the Jain community from Mumbai is very restricted by custom, marriage and occupation. We present here the HLA antigen distribution of individuals belonging to this endogamous community.

METHODS

A total of 161 healthy individuals of the Jain community working or studying in a hospital at Mumbai were selected randomly during 1985-1988. HLA class I and class II antigens were identified by using the standard National Institutes of Health (NIH) microlymphocytotoxicity assay.

RESULTS

The phenotypic frequencies of HLA A1, A2, A9, A11, A24, B5, B35, B40, Cw4, DR2, DR3, DR4, DR5 and DR7 were increased while frequencies of HLA A10, A19, A26, A32, B7, B14, B16, B21, B22, B27, B37, Cw2, DR1 and DR9 were decreased when compared with other populations from, Maharashtra. The phenotype frequencies of HLA A26, A28, A30, B18, B40, B56, Cw3, Cw4, DR3, DR4 and DR5 were increased while the frequencies of HLA B7, B15, B16, B22, B37, Cw2, Cw6, DR1 and DR9 were decreased when compared with frequencies in other Indian populations. Two locus haplotype analyses revealed that A9-B5, B35-Cw4, DR2-DQ1 and DR7-DQ2 were significant haplotypes among the positive linkage disequilibrium haplotypes. Whereas A9-B35, B35-Cw1 and DR1-DQ2 were significant haplotypes among the negative linkage disequilibrium haplotypes.

INTERPRETATION & CONCLUSION: The study revealed that the Jain population of Mumbai cannot be considered as a single panmictic population with reference to genetic characteristics, this may have a clinical relevance in unrelated donor selection for allogenic bone marrow transplantation in India.

摘要

背景与目的

印度人口以其遗传多样性而闻名。在众多的内婚制群体中，孟买的耆那教群体在习俗、婚姻和职业方面受到很大限制。我们在此展示了这个内婚制群体个体的HLA抗原分布情况。

方法

1985年至1988年期间，在孟买一家医院工作或学习的161名耆那教健康个体被随机选取。使用标准的美国国立卫生研究院（NIH）微量淋巴细胞毒性试验来鉴定HLA I类和II类抗原。

结果

与来自马哈拉施特拉邦的其他人群相比，HLA A1、A2、A9、A11、A24、B5、B35、B40、Cw4、DR2、DR3、DR4、DR5和DR7的表型频率增加，而HLA A10、A19、A26、A32、B7、B14、B16、B21、B22、B27、B37、Cw2、DR1和DR9的频率降低。与其他印度人群的频率相比，HLA A26、A28、A30、B18、B40、B56、Cw3、Cw4、DR3、DR4和DR5的表型频率增加，而HLA B7、B15、B16、B22、B37、Cw2、Cw6、DR1和DR9的频率降低。两位点单倍型分析显示，在正向连锁不平衡单倍型中，A9 - B5、B35 - Cw4、DR2 - DQ1和DR7 - DQ2是显著的单倍型。而在负向连锁不平衡单倍型中，A9 - B35、B35 - Cw1和DR1 - DQ2是显著的单倍型。