Kim S J, Nisperos B, Mickelson E, Choi I H, Dahlberg S, Kim J D, Giblett E R, Hansen J A
Hum Immunol. 1986 Nov;17(3):259-72. doi: 10.1016/0198-8859(86)90278-8.
The frequencies of HLA-A, B, C, DR, and DQ antigens, HLA-D (HTC-defined) haplotypes, and the HLA-linked genetic markers glyoxalase I (GLO), factor B (Bf), C2 and C4 were studied in 162 healthy unrelated Koreans. Antigens A2, A24, A26, B44, B51, Bw62, B35, Cw1, Cw3, DR2, DR4, DRw6, DR7, and DRw8 were observed at frequencies of 15% or greater, and GLO-2, BfS, C4A3, C2C, C4A4, C4B1, and C4B2 were also frequently observed. The antigens A23, A25, B18, Bw42, Bw47, and B21 were not observed at all. HLA-DR4 was the most common class II antigen and was associated with a series of HLA-D-defined haplotypes including Dw4, Dw10, Dw13, and Dw15. The HLA-DRw6, DR2,Dw8, and DRw8 haplotypes were also found frequently. DR2 haplotypes were either Dw2 or Dw12, while all DRw8 haplotypes tested corresponded to the DB7 or Dw "8.3" specificity that has been described in other Oriental populations. Significant linkage disequilibrium was found between the alleles A2,Cw1; A30,B13; A30,Cw6; A30,DR7; Cw1,Bw22; Cw5,B12; Cw6,B13; Cw6,DR7; B7,DR1; B12,Dw6; B12,DR7; B12,Dw7; B13,DR7, B17,DR3; Bw22,C4B6; DRw6,BfF; and C4A4,C4B*2. A comparison of gene frequencies and commonly observed haplotypes between Koreans, Chinese, Japanese, and Caucasians showed that while Koreans share several characteristics in common with other Oriental populations, there are allelic frequencies and haplotypes in Koreans that are distinct.
在162名健康、无亲缘关系的韩国人中，研究了HLA - A、B、C、DR和DQ抗原的频率、HLA - D（HTC定义）单倍型以及与HLA连锁的遗传标记乙二醛酶I（GLO）、B因子（Bf）、C2和C4。抗原A2、A24、A26、B44、B51、Bw62、B35、Cw1、Cw3、DR2、DR4、DRw6、DR7和DRw8的观察频率达到或超过15%，GLO - 2、BfS、C4A3、C2C、C4A4、C4B1和C4B2也经常被观察到。抗原A23、A25、B18、Bw42、Bw47和B21根本未被观察到。HLA - DR4是最常见的II类抗原，与一系列HLA - D定义的单倍型相关，包括Dw4、Dw10、Dw13和Dw15。HLA - DRw6、DR2、Dw8和DRw8单倍型也经常被发现。DR2单倍型要么是Dw2要么是Dw12，而所有测试的DRw8单倍型都对应于在其他东方人群中描述过的DB7或Dw“8.3”特异性。在等位基因A2与Cw1；A30与B13；A30与Cw6；A30与DR7；Cw1与Bw22；Cw5与B12；Cw6与B13；Cw6与DR7；B7与DR1；B12与Dw6；B12与DR7；B12与Dw7；B13与DR7；B17与DR3；Bw22与C4B6；DRw6与BfF；以及C4A4与C4B*2之间发现了显著的连锁不平衡。对韩国人、中国人、日本人及高加索人的基因频率和常见单倍型进行比较显示，虽然韩国人与其他东方人群有一些共同特征，但韩国人存在独特的等位基因频率和单倍型。
