Cavalli R, Gasco M R, Barresi A A, Rovero G
Dip. Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Italy.
Drug Dev Ind Pharm. 2001 Oct;27(9):919-24. doi: 10.1081/ddc-100107672.
Solid lipid nanoparticles (SLNs) have been proposed as alternative colloidal drug carriers. SLNs are obtained by dispersing warm oil-in-water microemulsions into cold water. The aim of this research was to investigate an evaporative drying process for aqueous dispersions of SLNs. For this purpose, a special apparatus, namely a thermostatic minidesiccator having alumina as the drying medium, was designed to carry out the evaporative drying at a controlled temperature. Besides the water removal kinetics, the mean particle size and the size distribution of SLNs were measured during the during with the aim of detecting the highest temperature at which the drying process can be carried out without significantly affecting the SLN average diameter. The SLN dispersions were evaluated with and without a hydrophilic excipient, commonly used as a cryoprotector (trehalose). The drying temperature of 10 degrees C was found to be the most suitable for obtaining SLNs as a powder, maintaining almost the same size as that of the SLNs in dispersion.
固体脂质纳米粒（SLNs）已被提议作为替代的胶体药物载体。通过将温热的水包油微乳液分散到冷水中可获得SLNs。本研究的目的是研究SLNs水分散体的蒸发干燥过程。为此，设计了一种特殊装置，即一种以氧化铝为干燥介质的恒温小型干燥器，用于在可控温度下进行蒸发干燥。除了水分去除动力学外，在干燥过程中还测量了SLNs的平均粒径和粒径分布，目的是检测在不显著影响SLN平均直径的情况下可进行干燥过程的最高温度。对添加和不添加常用作冷冻保护剂（海藻糖）的亲水性辅料的SLN分散体进行了评估。发现10℃的干燥温度最适合获得粉末状的SLNs，其尺寸与分散体中的SLNs几乎相同。
