Pshennikova M G, Belkina L M, Bakhtina L Iu, Baĭda L A, Popkova E V, Malyshev I Iu
Institute of General Pathology and Pathophysiology, Russian Acad. Med. Sci., Moscow, 125315, Baltiyskaya St., 8, Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Sep;87(9):1171-7.
A lesser resistance against myocardial infarction (MI) in the Wistar rats as compared with the August rats was found to be combined with a greater stress-response and activation of the heart sympathetic regulation in the former rats. In the Wistar rats and not in August rats, an activation of hypothalamic noradrenaline (NA) system occurs as well as a greater "output" of the NA from sympathetic terminals in the myocardium. Accumulation of the HSP 70 stress-proteins in IM in the myocardium is nearly 2-2.5-fold lesser in the Wistar rats. Thereupon, different resistance against the IM in Wistar and August rats seems to be due to a genetically determine differences in intensity of the stress-response, activation of the heart sympathetic regulation in the IM, and production of the HSP 70 protective stress-proteins in the myocardium.
与奥古斯特大鼠相比，发现Wistar大鼠对心肌梗死（MI）的抵抗力较弱，这与前者更大的应激反应和心脏交感神经调节的激活有关。在Wistar大鼠而非奥古斯特大鼠中，下丘脑去甲肾上腺素（NA）系统会被激活，并且心肌中交感神经末梢释放的NA“输出量”更大。Wistar大鼠心肌中IM处HSP 70应激蛋白的积累量比奥古斯特大鼠少近2 - 2.5倍。因此，Wistar大鼠和奥古斯特大鼠对IM的不同抵抗力似乎是由于应激反应强度、IM中心脏交感神经调节的激活以及心肌中HSP 70保护性应激蛋白产生的遗传决定差异。
