[长期束缚应激对雌性C57BL/6J和CBA/Lac近交系小鼠行为的影响。离散度与聚类分析]

[Effect of long-term restraint stress on behavior of female C57BL/6J and CBA/Lac inbred mice. Dispersion and cluster analysis].

作者信息

Avgustinovich D F, Liudvina N A, Dolgov V V, Alekseenko O V

机构信息

Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Division, Novosibirsk, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 2001 Sep;87(9):1268-82.

PMID:11763541

Abstract

An augmented exploratory behaviour and motor activity and diminished anxiety after a restraint stress were found in CBA/Lac female mice [corrected] but not in C57BL/6J ones. In the Porsolt test the result was exactly opposite. A possibility of inherent anxiety-depressive pathological condition in the C57BL/6J mice [corrected] developing under the effect of repeated psychological stress, is assumed.

摘要

在CBA/Lac雌性小鼠中发现，束缚应激后其探索行为和运动活性增强，焦虑减轻[校正后]，但C57BL/6J小鼠未出现此现象。在波索尔特测试中，结果正好相反。推测C57BL/6J小鼠[校正后]在反复心理应激作用下可能会出现内在的焦虑抑郁病理状态。