Sarlöv C, Andersén-Karlsson E, von Bahr C
Klinisk farmakologi, VO Medicin, Södersjukhuset, Stockholm.
Lakartidningen. 2001 Nov 21;98(47):5349-53.
Polypharmacy in patients with cardiovascular disease leads to an increased risk of developing adverse effects. At the Department of Internal Medicine at Stockholm Söder Hospital we studied computerized records and discovered that 14% of those hospitalized patients who were on drug treatment for cardiovascular diseases were admitted due to problems or symptoms possibly caused by their drugs. Interactions were less common; the symptoms which warranted hospitalization were more often caused by additive pharmacological effects. Obviously, adverse effects of drugs decrease quality of life, cause unnecessary suffering and treatment, and are expensive for the health care system. Screening of computerized records helps us detect adverse effects, and facilitates prevention.
心血管疾病患者的多重用药会增加出现不良反应的风险。在斯德哥尔摩南医院内科,我们研究了计算机化记录,发现因心血管疾病接受药物治疗的住院患者中,有14%是由于其药物可能导致的问题或症状而入院的。药物相互作用较少见;需要住院治疗的症状更多是由药物相加的药理作用引起的。显然,药物不良反应会降低生活质量,造成不必要的痛苦和治疗,对医疗保健系统来说成本高昂。筛查计算机化记录有助于我们发现不良反应,并促进预防。